17-Hydroxyprogesterone responses to gonadotrophin-releasing hormone agonist buserelin and adrenocorticotrophin in polycystic ovary syndrome: investigation of adrenal and ovarian cytochrome P450c17alpha dysregulation
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چکیده
منابع مشابه
17-Hydroxyprogesterone responses to gonadotrophin- releasing hormone agonist buserelin and adrenocorticotrophin in polycystic ovary syndrome: investigation of adrenal and ovarian cytochrome P450c17α dysregulation
to be elevated in .50% of patients with PCOS (Hoffman Departments of 1Obstetrics and Gynaecology and 2Endocrinology, et al., 1984). Using selective catheterization of the adrenal and Erciyes University, Faculty of Medicine, 38039 Kayseri, Turkey ovarian vessels, some hyperandrogenic women demonstrate 3To whom correspondence should be addressed significant adrenal androgen hypersecretion (Moltz ...
متن کاملLack of relationship between 17-hydroxyprogesterone response to buserelin testing and hyperinsulinemia in polycystic ovary syndrome.
OBJECTIVE To determine whether hyperinsulinism affects cytochrome P450c17 alpha activity by investigating the correlation between 17-hydroxyprogesterone (17-OHP) hyper-responsiveness to the gonadotropin-releasing hormone (GnRH) agonist, buserelin, and the insulin response to oral glucose in polycystic ovary syndrome (PCOS). DESIGN Ultrasound, clinical and hormonal parameters were used to defi...
متن کاملPulsatile gonadotrophin secretion in women with polycystic ovary syndrome after gonadotrophin-releasing hormone agonist treatment.
In polycystic ovary syndrome (PCOS), increased luteinizing hormone (LH) pulse frequency has been attributed to either the hypothalamic gonadotrophin-releasing hormone (GnRH) pulse generator or ovarian oestrogen feedback. To address this issue, a detailed examination of pulsatile LH secretion was undertaken during recovery from GnRH agonist (GnRHa) suppression. Each of six women with PCOS and si...
متن کاملEffect of gonadotrophin-releasing hormone agonist treatment on growth hormone secretion in women with polycystic ovarian syndrome.
The suppression of the pituitary-gonadal axis by the administration of gonadotrophin-releasing hormone agonists (GnRH-a) is used occasionally as an adjunct therapy with gonadotrophins for ovulation induction in women with polycystic ovarian syndrome (PCOS). A number of recent clinical studies have suggested that women with polycystic ovaries (PCO) may have disturbances of normal growth hormone ...
متن کاملAdrenal Contribution to Polycystic Ovary Syndrome
Objective: To examine further the dynamics of adrenal steroidogenesis in selected groups of patients with polycystic ovary syndrome (PCOS) compared to normal ovulatory women of the same age. Materials and Methods: Serum cortisol, testosterone, dehydroepiandrosterone sulphate (DHEAS), androstenedione (A), luteinizing hormone (LH), follicle-stimulating hormone, prolactin, 17hydroxyprogesterone (1...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 1997
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/12.5.910